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[DOI] [PMC free article] [PubMed] [Google Scholar] 169.Rohrer JD et al

These findings confirm that impairment of the blood-brain barrier and microglial, endothelial cell, ATPase, and astrocyte function exacerbate MDD

Thus, neurodegenerative diseases are multifactorial conditions involving various pathological mechanisms, and accordingly, they require complex therapeutic approaches