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Cagrilintide vs AOD 9604 Mechanism: Cagrilintide: Amylin receptor agonist (appetite/satiety) AOD 9604: HGH fragment (fat metabolism) Completely different Weight loss: Cagrilintide: 10-12% body weight AOD 9604: 5-8% body weight (less robust data) Cagrilintide superior Clinical evidence: Cagrilintide: Extensive Phase 2/3 trials AOD 9604: Limited clinical data Cagrilintide better studied Side effects: Cagrilintide: GI effects common AOD 9604: Minimal side effects AOD 9604 better tolerated Combination potential: Could theoretically combine (different mechanisms) No clinical data on combination Cagrilintide + semaglutide better established Verdict: Cagrilintide more powerful, better evidence

This paper is a comprehensive prospective casecontrol study that first reported the high prevalence of the metabolic syndrome in patients with HS, an observation most striking among young patients

Induction of testicular ischemia Testicular ischemia in rats was induced by the torsion and detorsion (T/D) of the left testis for 2 h, as described before 33

e-mail: [email protected] This article was submitted to Frontiers in Cellular Endocrinology, a specialty of Frontiers in Endocrinology