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In StatPearls [Internet]

In this regard, it can be noted that transcription of the gdhA gene initiates from two promoters, one weak, constitutively expressed, called gdhA P1, and another, more potent, called gdhA P2, transactivated by GdhR, a transcriptional regulator whose DNA binding is inhibited by -ketoglutarate (Pagliarulo et al., 2004)

The FDA label and clinical practice guidelines provide specific recommendations for safe combination therapy based on the hypoglycemia risk profile of each medication class

Experimental studies examine its potential impact on the integrity of the intestinal barrier and repair processes within the digestive tract