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However, because of the low integration rate associated with in vivo homologous recombination, in vivo expansion of corrected cells is needed to achieve therapeutic levels of expression [10]

Journal of Food Science and Technology, 47 , 290294

In addition to L-carnitine contribution to spermatogenesis, it can protect germ cells as an antiapoptotic factor by interfering with extrinsic Fas-FAS-Lmediated pathway (through intervening with Fas-triggered apoptotic signals and preventing ceramide generation) and intrinsic mitochondrial-dependent pathway (by inactivating caspases 3, 7, and 8) that are common effectors of apoptosis

acknowledges support from the National Institutes of Health (NIH) (P50CA272218) and the Melanoma Research Foundation