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Insufficient esterification of free cholesterol promotes ER stress and the recruitment of the E3 ligase RNF5, thereby activating CD36 ubiquitination in ACAT2-deficient intestinal cells

These results highlight the clinical potential of pretreatment molecular profiling as a strategy to guide therapeutic decision-making and optimize CF-based NAC in EC

While essential, excessive iron levels can be toxic, hence, its concentration must be tightly regulated within an optimal range

By mutating aminoacyl tRNA synthetases, chemists have expanded the genetic codes of various organisms to include lab-synthesized amino acids with all kinds of useful properties: photoreactive, metal-chelating, xenon-chelating, crosslinking, spin-resonant, fluorescent, biotinylated, and redox-active amino acids