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doi: 10.1056/NEJM199503023320904 57 WangNZhanYZhuLHouZLiuFSongPet al

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101-103 ( Figure 22 ), and found that 101-103 had a common motif, where the orientation of a primary amide was restricted by an adjacent hydrogen-bonding functionality, therefore, they tried to explore a new template based on the benzamide skeleton for developing IKK inhibitors [190]

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