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e , RASH3D19 expression levels in AsPC1, PANC1, MIAPaCa2, BxPC3 cells untreated or treated with pan-RAS inhibitor RMC7977 for indicated time

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Dashed arrows indicate negative feedback from circulating T 3 and T 4 to both the hypothalamus and pituitary gland, reducing TRH and TSH secretion

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