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The hyperinflammation associated with COVID-19 infection in children and adults (207210) affects all organs and tissues including atherosclerotic lesions ( Figure 7 ) and is always associated with very high levels of CRP, that enhance and amplify the inflammatory and prothrombotic microenvironment, most certainly mediated by increased generation of mCRP, which could also contribute to plaque instability through the demonstrated CRP-induced expression of matrix metalloproteinases 1, 2, and 9 (154)