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This is in contrast with the generation of reactive oxygen species triggered by the standard radiation, at a lower dose but for a longer time than FLASH-RT, leading to the PPAR activation and consequent lipid peroxidation

Definition ChEBI: Gly-His-Lys is a tripeptide composed of glycine, L-histidine and L-lysine residues joined in sequence

A higher 5-Amino-1MQ dosage might be necessary in subjects with advanced metabolic dysfunction to achieve a noticeable effect

On the other hand, metabolic syndrome (MetS) is a constellation of symptoms that implies a higher risk for CVD and type 2 diabetes (T2D), increasing the morbidity and mortality of these patients