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34 In a similarly sized double-blind, placebo-controlled study of intravenous ketamine (0.2 mg/kg) for treatment of migraine in the emergency department setting, however, ketamine was not superior to placebo for acute pain relief and caused adverse effects of generalized discomfort at 30 minutes and fatigue at 60 minutes, although no serious adverse events occurred

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These alterations can persist over time, allowing plants to respond more rapidly to future cold exposure

AST, located in the cell membrane, scavenges free radicals, preserves membrane structure, enhances immune performance, and regulates gene expression, protecting cells from oxidative damage and maintaining tissue integrity 21,22