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Subjective symptom assessment provides one measure, but objective markers can be valuable: Pain scales: VAS or NRS scores at baseline and regular intervals Functional measures: activities possible, sleep quality, energy levels Metabolic markers: if relevant, HbA1c and lipid panels Nerve function tests: if available, quantitative sensory testing Understanding how long peptides take to work sets appropriate expectations

BPC-157 equaled or exceeded imipramine (a standard tricyclic antidepressant) in reducing immobility in forced swimming tests, the gold-standard model for screening antidepressant drugs