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This suggests a potential combination therapy for enhancing endothelial function

Administration of 0.01 mg/kg WAY 100635 (i.p.) completely eliminated the lower lip retraction produced by 1.0 mg/kg dose of ipsapirone (Figure 5, top left panel, squares with cross hatch

The mitragynine model, optimized using a logP of 4.8, captured the observed biphasic profile up to 120 hours from our previous (training dataset) study