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Sting would continue to lead the group

However, under conditions of sustained tumoral stress and prolonged receptor activation, we propose that nuclear accumulation of ATF4 may render it more susceptible to turnover mechanisms such as proteasomal degradation, which is in contrast to its canonical role initiating integrated stress response (ISR) [58, 59]

[3] This is a known effect and not cause for concern

We refer readers to our fact sheets for more information about these analyses and our findings at: (for the CY 2022 performance period/2024 MIPS payment year) and (for the CY 2023 performance period/2025 MIPS payment year)