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Human lipoxygenase pathway gene variation and association with markers of subclinical atherosclerosis in the diabetes heart study

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However, it is not understood which pathways involved in protecting cells from oxidative stress may be modulated by the circadian system

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This inhibition results in a lipid overload state, where non-oxidized fatty acids are diverted into pathways generating more ceramides, perpetuating a self-amplifying cycle of metabolic stress and dysfunction (Serra et al., 2013)

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