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Many of the symptoms of EDS or Hypermobility are due to leaky connective tissue which causes an excessively active immune system, which is associated with PE since the Parasympathetics control the immune system

This process enhances epithelial-to-mesenchymal transition (EMT), a critical step in cancer metastasis

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Briefly, 100 mg of frozen tissue were extracted in 300 l of 40:40:20 acetonitrile:methanol:water with 1 nM final concentration of d 3 N 15 serine (Cambridge Isotope Labs)