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In this perspective, we will review the data regarding intestinal paracellular transport, providing views based on the preponderance of the available data regarding the mechanisms of intestinal transport of solutes, bacteria, and bacterial toxins in relation to paracellular permeability with the primary objective of contrasting the intestinal transport pathways for intact bacteria and bacterial toxins such as LPS with the paracellular pathways by which ions and small organic molecules are transported across the mucosa

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A deficiency in B12 can also impact nerve production, leading to a loss of muscle mass

Published evidence is summarized lower on the page