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FIGURE 2 3.1 IRE1-XBP1 pathway Inositol-Requiring Enzyme 1 (IRE1) is an evolutionarily conserved ER stress sensor and an I-type transmembrane protein in the endoplasmic reticulum of all eukaryotes, including yeast and humans, playing a key role in maintaining endoplasmic reticulum homeostasis (Adams et al., 2019)

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Our metabolomics analysis in neutrophils isolated from T2D individuals also showed increased sorbitol levels [15]