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A mutation within the LIPT1 gene can lead to fatal disorders that are associated with impaired lipoylation of 2-ketoacid dehydrogenase [72,73]

American Journal of Physiology-Endocrinology and Metabolism Jornayvaz FR, Jurczak MJ, Lee H-Y, Birkenfeld AL, Frederick DW, Zhang D et al (2010) A high-fat, ketogenic diet causes hepatic insulin resistance in mice, despite increasing energy expenditure and preventing weight gain

This event increases the amount of 5,10-methyleneTHF available to be channelled into de novo thymidylate synthesis

Catalytic mechanism of pFeSAN To verify the dependence of the oxidase-like activity of pFeSAN on oxygen, taking it as a control in air, nitrogen, or oxygen was introduced into the reaction flask for 30 min before measuring oxidase-like activity