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doi: 10.1080/00365521.2022.2071109 287 DiNicolantonioJJLucanSCOKeefeJH

Next, we downloaded the ferroptosis driver and suppressor genes from the FerrDb database 27 and imported them into the RStudio software to calculate the ferroptosis driver and suppressor scores in the seven clusters, respectively

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PFK-2 regulates intracellular levels of the glycolytic intermediate fructose-2,6-bisphosphate (F-2,6-BP), as it has dual kinase:bisphosphatase activities and thus catalyzes both the synthesis and degradation of this intermediate