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The findings from current study align with previous proteomic studies of liver organoids, which have demonstrated their capacity to recapitulate liver-specific phenotypes

Pathway profile score was generated from nSolver Analysis Software using the 23 neurodegenerative pathways mentioned previously

Oral nutritional supplement (ONS) that contains -hydroxy--methyl butyrate (HMB), L-arginine, and L-glutamine serves as effective prophylactic supplementation for Hand-foot skin reaction (HFSR) caused by sorafenib in advanced HCC patients (Naganuma et al., 2019)

For the five families from the UK, according to the institutional review board (IRB) no formal research ethics approval or research and development approval was required as stipulated by the UK policy Framework for Health and Social Care Research and the Health Research Authority decision tool