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Consistent with cell-autonomous effects, the epigenetic control of OPC differentiation into myelinating OLGs is disrupted with aging (Shen et al., 2008), and the OPCs of aged mice fail to respond to growth factors and differentiation signals (Neumann et al., 2019)

Library quality control was performed on the fragment analyser (HS NGS kit) and Qubit

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However, this technique is more complex and expensive than other chromatography methods