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Phytochemicals as Nrf2 inducers Despite the clinical success of some Nrf2 activators, their broad electrophilic reactivity with proteins containing reactive cysteine residues leads to significant off-target effects and challenges in achieving precise therapeutic outcomes, thereby presenting substantial barriers to clinical translation

Cara yang bertindak GSH dalam sel adalah bahwa keadaan redoks pasangan glutathione disulfida glutathione sangat penting untuk kesehatan antar sel dan cairan intraseluler

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3.2 Therapeutic potential via paracrine mechanisms The therapeutic effects of MSCs are primarily mediated through their paracrine activity, which involves the secretion of bioactive factorssuch as growth factors, chemokines, cytokines, and EVsto modulate the local microenvironment (Pittenger et al., 2019