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Furthermore, it is vital to promptly recognize signs of uncontrolled asthma that require therapeutic escalation or the introduction of biological therapies

41,42,43 Another comparative study of 90 patients with OSF and 130 healthy controls also reported the GST variantsGSTM1 and GSTT1, increase the risk of OSF progression in the North Indian population

These cells secrete various mediators that are directly responsible for the progression of allergy and bronchial obturation in asthma ( de novo synthesized prostaglandin D2 (PGD2), leukotriene C4 (LTC4), adenosine, and ROS are released from mast cell granules ( Figure 1 )

Additionally, these alternatives would introduce additional scoring complexity and in one case, require clinicians' additional submission of a reweighting application to access potential benefits