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The outcomes of this phase III clinical trial demonstrated significant superiority over those of the control group, leading to the approval of Cx601 (Alofisel) for the treatment of complex perianal fistulas in patients with Crohns disease, which received approval in March 2018 within the European Union and in October 2021 in Japan

All the statistical analyses and data visualisations were performed via GraphPad PRISM (v.9.5.1)

plantarum possesses a putative homolog of bifunctional fusion protein gshF [6, 25], however, GSH synthesis in this organism has not been reported but it may uptake GSH from the medium [21, 34]

These toxins enter our body through ingestion, absorption, and inhalation