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Variations in the genes encoding iNOS and neuronal nitric oxide synthase (nNOS) have been associated with increased susceptibility to MDD [136]

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Gene expression analysis revealed that compound 2 promotes apoptosis by upregulating pro-apoptotic genes Bax and Caspase 3 and downregulating the anti-apoptotic gene, Bcl-2

Similarly, the higher abundance of Salmonella and its associated lineage Salmonella enterica in the T1 group may reflect habitat- driven exposure to particular pathogens or environmental stressors that select for these bacteria