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E.TluczkiewiczI.BatkeM.BitschA.MelberC.KroeseE

At this time, immunotherapy shows great potential in a variety of tumor clinical treatments, however, its clinical effect in glioma is limited because of tumor immune privilege which was induced by the glioma immunosuppressive microenvironment, so remodeling the immunosuppressive microenvironment is a practical way to eliminate glioma immunotherapy resistance

It is estimated that of all phase I trials, roughly 63% make it to phase II, 31% make it to phase III, and only 9.6% make it through the entire three-stage trial (5)

Some researchers have speculated that melatonin may act as a glycolytic agent similar to the anticancer drug DCA, targeting the mitochondria of metabolically reprogrammed cancer cells