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Measurement of superoxide dismutase (SOD) activity The level of superoxide dismutase (SOD) activity in liver homogenate was determined using the method outlined by Nandi and Chatterjee 42

Abbreviations 5-HIAA: 5-Hydroxyindoleacetic acid 5-HT: 5-Hydroxytryptamine 5-HTP: 5-Hydroxytryptophan 5-MTHF: 5-Methyltetrahydrofolate 8-OHdG: 8-Hydroxy-deoxyguanosine ABC: Autism Behavior Checklist ASD: Autism spectrum disorder BMI: Body mass index CARS: Childhood Autism Rating Scale DHF: Dihydrofolate DQ: Developmental quotient GABA: -Aminobutyric acid GDS: Gesell Developmental Scale GI: Gastrointestinal Hcy: Homocysteine LCMS: Liquid chromatography-mass spectrometry NAC: N-acetylcysteine PLS-DA: Partial least squares discriminant analysis SRS: Social Responsiveness Scale TD: Typically developing TPP: Thiamine-pyrophosphate VAD: Vitamin A deficiency VIP: Variable important in projection Reference Abdulamir HA, Abdul-Rasheed OF, Abdulghani EA

A variety of cellular stresses, including DNA damage can cause the induction of cellular senescence, which represents a multifaceted and highly heterogeneous cellular state characterized by irreversible growth arrest and importantly the secretion of a multitude of factors, including proteases and chemokines 2

Schrdinger, L