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The role of mitochondrial dysfunction in Huntingtons disease: implications for therapeutic targeting

Since glutathione, which is ultimately a metabolic intermediary, is transported by so many of the MRP transporters, I backtracked its metabolic pathway MRP Isoforms There are 12 known human isoforms as summarised - MRP1 Long MRP Role excretes a broad range of endogenous and exogenous substances

16 It has been shown that influenza viruses induce oxidative stress mediated by an excess of ROS and a decrease of reduced glutathione, and that such conditions favour viral replication, with glutathione depletion pivotal for the folding and maturation of the viral glycoprotein and therefore viral replication

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