nax signals the body to produce l glutathione is critical for NK cell-mediated immunity: Cell Reports NOX-like ROS production by glutathione

In light of these observations and the fact that MavL was identified in our screening strategy based on ubiquitin interaction, we further pursued the hypothesis that MavL acts on proteins that have been modified by ubiquitination, ADP-ribosylation, or both

Esculin, a glycosylated, water-soluble prodrug, becomes active only after hydrolysis to esculetin by -glucosidases produced by dermatophytes and skin microbiota, enabling in situ activation on infected skin

doi: 10.1021/jf101077s 118 WeissmanK

It utilizes glutathione (GSH) as a cofactor to neutralize lipid peroxides, thereby preventing lipid-associated ROS accumulation and potentially leading to ferroptosis