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Similarly, oral administration of steviol glycosides at doses up to 1,880 mg/kg for 4 weeks caused only mild increases in oxidative damage and chromosomal abnormalities in mice, whereas no genotoxic effects were observed at doses as high as 8,000 mg/kg in vivo (Orellana-Paucar, 2023)

Since 1940 sulfasalazine has been in use for the treatment of RA (29) and the triple DMARD therapy that combines hydroxychloroquine, sulfasalazine and methotrexate is still the first choice of treatment for most rheumatologists (30)