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no human validation Approach Published mouse regimen Pattern 5 mg/kg IP, ~3x/week Duration Several weeks Notes Animal only

Most researchers regain 1 to 3 pounds in the first two weeks off (primarily water weight and increased GI contents), then 1 to 2 pounds per month thereafter as appetite normalizes and caloric intake creeps back up

13 Suppression of NLRP3 inflammasome with the administration of MCC950, enhanced RV function in MCT-treated rats while reducing monocyte-induced hypertrophy and mitigating mitochondrial damage in normal CMs in vitro

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