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A final alternative to alleviate FcRn-controlled pathological mechanisms could be to alter FcRn in itself, as may be intended with a gene therapy being developed in a collaboration between Beam and Apellis for a one-time dose of gene-editing molecules targeting FcRn [436, 437]

Injections quickly correct severe cases and absorption problems, while oral regimens suit many with mild or moderate deficiency, offering convenience and cost savings

While both solutions serve similar functions, they are distinct in their compositions and applications

To determine the efficacy of the treatment, the researchers utilized the Clinical Global Impressions Improvement (CGI-I) scale after the 8-week study period