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Pore pathway Water, ions, and nutrients are transported via the pore pathway

Research indicates that it enhances production of melatonin, contributing to the regulation of melatonin levelsa key factor in maintaining healthy circadian rhythms and deep sleep

Given the important central role of this cofactor and its relevance to mitochondrial function, this review will provide an extensive summary of the NAD + homeostasis and modulation approaches, of the various mechanisms of NAD + -mediated mitochondrial regulation, and how the functional link between NAD + and mitochondria has been investigated in the context of preclinical and clinical settings of aging and disease