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As the mitral valve degenerates, the valve no longer fully closes after each pumping action, allowing some blood to flow backwards through them from the ventricle back into the atrium

Other candidates, such as compound 3 from the NCI-3D database 200 , DIMN analogs termed 7AU and 7BB 201 , and MEL-3 202 , all showed encouraging in vitro activities and need to be tested in animal models

Peer review Peer review information Nature Reviews Cancer thanks Dong Gao and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

This leads to a reduced ability of the heart to pump blood effectively, causing a range of health issues, like reduced exercise tolerance, arrhythmias (irregular heartbeats) and congestive heart failure, where fluid builds up in the lungs or abdomen