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Indeed, several studies have gathered evidence of the intricate interactions between skin-resident microbes and host cells in shaping a disease-promoting environment [19, 20]

Since moonlighting behaviour of hPrdx6 is triggered by the micro-environment (i.e., cytosolic and lysosomal), the primary difference is pH (pH 7.0 for cytosol and 4.0 for lysosome)

Early in AD, APP-CTF accumulation to abnormally high levels in neuronal lysosomes more strongly inhibits the association of the V1 subcomplex with the V0 subcomplex, causing a pathological lysosomal pH rise 121 and impaired substrate hydrolysis

Representative systems include Fe-HMME@DHA@MPN