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Alcohol Res Health 30(1):1821 Duester G et al (1999) Recommended nomenclature for the vertebrate alcohol dehydrogenase gene family

Nervonic acid has been studied for its effects on immune function in RAW 264.7 macrophages, where it has been found to activate NF-B signaling, leading to the increased production of pro-inflammatory cytokines (e.g., TNF- and IL-6) as well as enhanced nitric oxide (NO) and ROS generation in concentrations of 12.5 M or higher ( In animal models, such as in JCR rats (a model of obesity), vaccenic acid (C18:1 trans-11), a precursor to trans fats derived from ruminants, has been shown to suppress pro-inflammatory lymphocyte activity and improve the inflammatory profile of mesenteric lymphocytes ( Table 3 )

This neural signaling underlies the generation of sickness behaviors (e.g., fatigue and anorexia) [324] and can further initiate neuroimmune changes, including microglial activation [325, 326]

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