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A simplistic underlying hypothesis is that mtDNA polymorphisms might impact energy metabolism during both a resting state, by decreasing the ability to preserve transmembrane ion gradients and hence predisposing to a hyperexcitability state, and during stress circumstances by failing to mount a greater energy supply for increased demand

Hlais, S., Reslan, D

Power calculation for the associations of genetically predicted l-carnitine and acetyl-carnitine with cardiovascular disease and its risk factors

Carnitine content and expression of mitochondrial beta-oxidation enzymes in placentas of wild-type (OCTN2(+/+)) and OCTN2 Null (OCTN2(/)) Mice