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This approach ensures that the nanomaterial will be activated primarily in the vicinity of pathogenic bacteria, which thrive in such environments and will remain inactive in the more neutral pH of healthy tissues, pH-responsive NPs are commonly made using materials like chitosan, which undergoes protonation in acidic conditions, leading to a release of encapsulated drugs or antimicrobial agents at infection sites

Acta Chem Scand 36:389395 Folkers K, Feng DM, Asano N, Hkanson R, Wiesenfeld-Hallin Z, Leander S (1990) Spantide II, an effective tachykinin antagonist having high potency and negligible neurotoxicity