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Clinical Field Study: Effectiveness was evaluated in 177 dogs (121 dogs in the ENTYCE group and 56 dogs in the vehicle control group) in a double-masked, vehicle controlled field study

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Additionally, treatment with the essential oil enhanced Akt kinase phosphorylation, with partial inhibition observed using the PI3K/Akt inhibitor (LY294002), indicating the involvement of the PI3K/Akt pathway