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Another key concern regarding gene editing revolves around establishing regulatory frameworks for the technology and determining whether genetically edited crops should be classified as GMOs or not

These results indicate that MITOL adds K63-linked polyubiquitin chains to HMOX2

RK: Writing review & editing

First, mechanistic studies should integrate single-cell transcriptomics and spatial metabolomics to map cell-type-specific ferroptosis pathways in hippocampal and cortical neurons and microglia, with particular focus on the link between NCOA4-mediated ferritinophagy and A clearance, thereby building a dynamic model connecting iron dysregulation, proteotoxic stress, and cell death