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Furthermore, according to this study, Set7/9 was shown to act, in contrast to PGC-1, as a positive regulator of NFkB, hence activating the NFkB-dependent pro-inflammatory gene expression program

A study showed that probiotic-fermented Pueraria lobata (Willd.) Ohwi significantly reduced the abundance of Bacteroidetes and Akkermansia muciniphila while increasing the abundance of Firmicutes and Lactobacillus , which modulated aberrant gut microbiota composition and activated nuclear transcription factor (erythroid-derived 2)-like 2 (Nrf2)-mediated signals, thereby improving lipid accumulation and inflammation and exerting antioxidant effects and ultimately preventing ALD ( in vivo and in vitro , which is inseparable from its impact on the gut microbiota ( Table 1 Research overview of TCMs and NPs targeting gut microbiota for liver disease therapy

Meili-Butz, S., Niermann, T., Fasler-Kan, E., Barbosa, V., Butz, N., John, D., et al