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Oxidative stress and hypoxia modulate cellular networks via transcriptional regulators, such as HIF-1-mediated induction of BNIP3/NIX, to promote mitophagy, [] as well as through direct protein modifications, such as the redox-sensitive oligomerization of MFNs that regulates mitochondrial fusion

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As previously discussed, (see leptin), three trials addressing the weight loss efficacy of the combined treatment over 20, 28, and 52 weeks, respectively) reported sustained and robust weight loss by the combined treatment