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doi: 10.1016/j.gene.2019.143956 115 LimDYJeongYTynerALParkJHY

Apoptotic/dead cells detection Dead and apoptotic cells were detected using the CellEvent Caspase-3/7 Kit (#C10423, Thermo Fisher Scientific) according to the manufacturers recommendations

The combination protocol increases the number of dose escalation events (since you are titrating two compounds), which may mean more frequent but generally mild headaches