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Ohnuma T, Holland JF, Nagel G, Arneault GS

In disorders such as RTD, MADD, and AIFM1-related encephalopathy, riboflavin supplementationwhether alone or in combination with genetic or pharmacological modulationhas shown promise in stabilizing disease progression and restoring enzyme function

While compounded drugs are not FDA-approved, certain compounding may be permitted under sections 503A and 503B of the Federal Food, Drug, and Cosmetic Act in limited circumstances (such as drug shortages)