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(4) Metabolite synergy: BBR metabolites (berberrubine (BBB), palmatine (PMT)) reverse obesity-associated Akt pathway inhibition, ameliorating cell death, oxidative stress and mitochondrial dysfunction in HFD-fed mice [164]

Notably, the P values for these genes were substantially more significant, and the fold changes in their differential expression levels were greater in the combination group than those in the single-natural product groups (Fig