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In contrast, pretreatment with GYY4137 dramatically increased the expression of antioxidative marker SOD in inflammatory macrophages

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the activation of HIF-1 may be a result of elevated ROS which stabilize this transcription factor by activating prolyl hydroxylases (36, 37)

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Research Square Preprint2024 Jan 18

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Furthermore, metabolic diseases including insulin resistance, diabetes and NAFLD are linked to cognitive dysfunction including depression and dementia (Tomeno et al., 2015

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