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The rationale for our hypothesis is that the electrophilicity of EA represented by the ,-unsaturated ketone moiety facilitates an irreversible chemical reaction with the highly nucleophilic Cys314 residue in the catalytic triad of FXIIIa, which is the only transglutaminase among all clotting factors, resulting in its inhibition [16, 17]

Astrocyte Contribution to Dysfunction, Risk and Progression in Neurodegenerative Disorders. Nature Reviews

Comparative analysis of gut microbiota in patients with irritable bowel syndrome and healthy controls