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CJC-1295 CJC-1295 is also generally well-tolerated, but its longer activity can occasionally cause mild water retention, joint stiffness, or increased appetite in some individuals

However, this theory has largely fallen out of favor due to a number of discrepancies, such as the fact that the therapeutic effects of antidepressants take weeks to develop even though monoamine levels are elevated within hours of administration, and the fact that only about 40% of patients respond satisfactorily to treatment (Trivedi et al., 2006)

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Nuclear DNA damage after acetaminophen overdose is likely to be caused by DNase(s) unrelated to the caspase-activated DNase, which is typically responsible for DNA fragmentation during apoptosis