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A dose-dependent decrease in body weight was shown, ranging from -1.3 kg in the placebo group to -1.4 kg in the 0.03 mg/kg leptin-treated group, and to -7.1 kg in the 0.30 mg/kg leptin-treated group (8)

IGF-1 LR3 added at the start of the same experiment maintains receptor-available concentrations for much longer

The theoretical basis centres on supporting hepatic fat metabolism whilst simultaneously reducing caloric intake and improving insulin sensitivity through pharmacological means