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The most frequently reported adverse reactions are light-headedness, dizziness, sedation, nausea and vomiting

doi: 10.1002/eji.201646477 50 HaasRSmithJRocher-RosVNadkarniSMontero-MelendezTDAcquistoFet al

Aoyagi et al

Elevated insulin levels stimulate the production of Insulin-Like Growth Factor 1 (IGF-1), a growth hormone with several downstream effects on the skin